Fluorine F 18 PARP Inhibitor

**Semantic type:** Pharmacologic Substance

**Definition:** A radiotracer consisting of a 1(2H)phthalazinone-based poly(ADP-ribose) polymerase 1 (PARP1) inhibitor (PARPi) radiolabeled with the positron emitting isotope fluorine F 18, which can potentially be used for the imaging of PARP1 expression using positron emission tomography (PET). Upon administration, fluorine F 18 PARPi targets and binds to PARP1. Upon PET, PARP1-expressing tumor cells can be visualized. PARP1, which is overexpressed in many cancer cell types, catalyzes post-translational ADP-ribosylation of nuclear proteins and plays a key role in the repair of DNA strand breaks.

**Synonyms:** - 18F Fluorinated PARP1-targeted Probe - 18F-1(2H)phthalazinone-based PARPi Imaging Agent - 18F-radiolabeled 1(2H)phthalazinone PARPi - Fluorine F 18 PARPi - Fluorine F 18 Poly(ADP-ribose) Polymerase Inhibitor - [18F]PARP1-targeted Probe - [18F]PARPi - [18F]PARPi Imaging Agent