Autologous CD30CAR-CD28-CD3zeta-expressing T-Lymphocytes

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of autologous T-lymphocytes (ATL) that have been transduced with the retroviral vector SFG, a Moloney murine leukemia (Mo-MuLV) virus-based vector, encoding a chimeric antigen receptor (CAR) composed of a single chain single-chain variable fragment (scFv) directed against the CD30 antigen (CAR.CD30) and linked, via the spacer human IgG1 immunoglobulin heavy constant region (hinge-CH2CH3 region), to the co-stimulatory domains of CD28 and the zeta chain of the TCR/CD3 complex (CD3-zeta) (CD28zeta), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous CD30CAR-CD28-CD3zeta-expressing T-lymphocytes specifically recognize and bind to CD30-expressing tumor cells, resulting in specific T-cell-mediated tumor cell lysis. CD30, a cell surface receptor and a member of the tumor necrosis factor (TNF) receptor superfamily, is transiently expressed on activated lymphocytes and is constitutively expressed in hematologic malignancies.

**Synonyms:** - ATL-expressing CD30-CAR-CD28zeta - ATLCAR.CD30 Cells - ATLCAR.CD30-CD28zeta Cells - Anti-CD30-CAR/CD28z Retroviral Vector-transduced Autologous T-Cells - Autologous CAR-CD19-CD28-zeta-transduced T-lymphocytes - CAR-CD30-28zeta-specific Autologous T-cells - SFG.CAR.CD30 Autologous T-lymphocytes