Autologous Ovarian Cancer-specific Cytotoxic T-Lymphocytes

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of autologous cytotoxic T-lymphocytes (CTLs) genetically modified to target a not yet disclosed ovarian cancer-specific tumor-associated antigen (TAA), with potential immunomodulating and antineoplastic activities. After isolation, transduction, expansion in culture, and reintroduction into the patient, the autologous ovarian cancer-specific cytotoxic T-lymphocytes (OC-CTLs) bind to and induce selective toxicity in tumor cells expressing the TAA.

**Synonyms:** - Autologous OC-CTLs - Autologous Ovarian Cancer-specific CTLs - OC-CTLs