Gallium Ga 68-NOTA-anti-HER2 Nanobody VHH1

**Semantic type:** Amino Acid, Peptide, or Protein|Indicator, Reagent, or Diagnostic Aid|Pharmacologic Substance

**Definition:** A radioconjugate composed of a nanobody directed against human epidermal growth factor receptor 2 (HER2, EGFR2, ERBB2) that is linked, through the macrocyclic chelating agent 1,4,7-triazacyclononane-N,N',N''-triacetic acid (NOTA) to the radionuclide gallium (Ga) 68, with potential use in diagnostic imaging using positron emission tomography/computed tomography (PET/CT). Upon administration of gallium Ga 68-NOTA-anti-HER2 Nanobody VHH1, the anti-HER2 antibody moiety targets and binds to HER2-expressing cells. This facilitates both detection of HER2-expressing tumor cells and assessment of responses to HER2-targeted chemotherapeutic agents during PET/CT. HER2, a tyrosine kinase is overexpressed on the cell surfaces of various tumor cell types.

**Synonyms:** - 68Ga-HER2-Nanobody VHH1 - 68Ga-NOTA-2Rs15d - 68Ga-NOTA-anti-HER2 VHH1 - Gallium Ga 68-NOTA-anti-HER2-VHH1 - VHH1