Autologous Anti-CD38 A2 CAR2-expressing T-cells

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of genetically modified autologous T-cells expressing a chimeric antigen receptor recognizing the tumor-associated antigen (TAA) cluster of differentiation 38 (CD38), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, autologous anti-CD38 A2 CAR2-expressing T-cells are directed to and induce selective toxicity in CD38-expressing tumor cells. CD38, a type II transmembrane glycoprotein, is present on various immune cells and hematologic malignancies, and its expression has been correlated with poor prognosis.

**Synonyms:** - Autologous Anti-CD38 A2 CAR2 T-cells - Autologous CAR2 Anti-CD38 A2 CAR T-cells - Autologous CAR2 Anti-CD38 A2 T-lymphocytes - Autologous CD38-A2 CAR2-expressing T-lymphocytes