Autologous Anti-CD22 CAR-4-1BB-TCRz-transduced T-lymphocytes CART22-65s

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** Autologous human T-lymphocytes transduced with a recombinant lentiviral vector encoding a chimeric antigen receptor (CAR) consisting of an anti-CD22 human single chain variable fragment (scFv) and linked to the co-stimulatory domain 4-1BB (CD137) coupled to the zeta chain of the TCR/CD3 complex (CD3-zeta), with potential immunostimulating and antineoplastic activities. Upon reintroduction into the patient, the autologous anti-CD22 CAR-4-1BB-TCRz -transduced T-lymphocytes CART22-65s express anti-CD22-CAR on their cell surfaces and bind to the CD22 antigen on tumor cell surfaces, resulting in lysis of CD22-expressing tumor cells. CD22, a B-lineage-restricted, transmembrane phosphoglycoprotein, is expressed on malignant B-cells.

**Synonyms:** - Autologous Anti-CD22 CAR T-Cells CART22-65s - Autologous Anti-CD22 scFv CAR 4-1BB-TCRz-expressing T-lymphocytes CART22-65s - Autologous CART22-65s Cells - Autologous CART22-65s T-cells - Autologous CART22-65s-expressing T-cells - CART22-65s