Partially HLA-matched AdV/CMV/EBV-specific Allogeneic T-Lymphocytes

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** Partially or closely human leukocyte antigen (HLA)-matched allogeneic cytotoxic T-lymphocytes (CTLs), derived from cell lines, specifically reactive to the three human viruses adenovirus (AdV), cytomegalovirus (CMV) and Epstein-Barr virus (EBV), with potential antiviral activity. Upon infusion of the partially HLA-matched AdV/CMV/EBV-specific allogeneic T-lymphocytes in immunocompromised patients or upon allogeneic hematopoietic stem cell transplantation (HSCT) in an immunodeficient recipient, these CTLs may kill AdV, CMV, and/or EBV-infected cells, and may prevent or reduce the severity of viral infections by these pathogens.

**Synonyms:** - Allogeneic HLA-matched VSTs - Allogeneic HLA-matched Virus-specific T-cell Lines - Allogeneic Partially HLA-matched AdV/CMV/EBV-specific T-cells - Partially HLA-matched AdV/CMV/EBV-specific Allogeneic T-cells - Partially HLA-matched Adenovirus/Cytomegalovirus/Epstein-Barr Virus-specific Allogeneic Cytotoxic T-Lymphocytes