High Risk Chronic Myelomonocytic Leukemia

**Semantic type:** Finding

**Definition:** Chronic myelomonocytic leukemia with cytogenetic abnormalities including trisomy 8, complex karyotypes, monosomy 7, and del17q. Mutations in RUNX1, NRAS, SETBP1, and ASXL1 are independently associated with inferior overall survival time. (Oncology Letters 15:7132-7138, 2018)

**Synonyms:** - High-Risk Chronic Myelomonocytic Leukemia