Para-toluenesulfonamide

**Semantic type:** Pharmacologic Substance

**Definition:** A low-molecular-weight organic compound with potential antineoplastic activity. Upon intra-tumoral injection, para-toluenesulfonamide increases lysosomal membrane permeabilization (LMP) and the release of cathepsin B. Cytosolic cathepsin B released from lysosomes cleaves and activates proapoptotic B-cell lymphoma 2 (Bcl-2) family member BH3 interacting-domain death agonist (Bid) and poly [ADP-ribose] polymerase 1 (PARP-1), which may induce tumor cell death.

**Synonyms:** - P-TOLUENESULFONAMIDE - PTS - PTS 100 - PTS-100 - PTS100