Runimotamab

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** An anti-human epidermal growth factor receptor 2 (HER2)/anti-CD3 T-cell-dependent bispecific (TDB) monoclonal antibody with potential immunostimulatory and antineoplastic activities. Upon administration, runimotamab possesses two antigen recognition sites, one for HER2, a tyrosine kinase receptor overexpressed by many cancer cell types, and one for the CD3 complex, a group of T-cell surface glycoproteins that interact with the T-cell receptor (TCR). Upon administration of runimotamab, this bispecific monoclonal antibody simultaneously binds to both CD3-expressing T-cells and HER2-expressing cancer cells, thereby crosslinking HER2-expressing tumor cells and cytotoxic T-lymphocytes (CTLs). This may result in potent CTL-mediated lysis of HER2-expressing tumor cells. HER2 plays a key role in tumor cell proliferation and tumor vascularization.

**Synonyms:** - Anti-HER2 x Anti-CD3 Bispecific Monoclonal Antibody BTRC 4017A - Anti-HER2 x Anti-CD3 Bispecific Monoclonal Antibody RG 6194 - Anti-HER2/Anti-CD3 Bispecific Monoclonal Antibody 4017A - Anti-HER2/Anti-CD3 Bispecific Monoclonal Antibody BTRC 4017A - BTRC 4017A - BTRC-4017A - BTRC4017A - RG 6194 - RG-6194 - RG6194 - RUNIMOTAMAB