Murizatoclax

**Semantic type:** Pharmacologic Substance

**Definition:** An inhibitor of induced myeloid leukemia cell differentiation protein (myeloid cell leukemia-1; Mcl-1; Bcl2-L-3), with potential pro-apoptotic and antineoplastic activities. Upon administration, murizatoclax targets and binds to Mcl-1, thereby preventing the binding of Mcl-1 to and inactivation of certain pro-apoptotic proteins. This promotes apoptosis of cells overexpressing Mcl-1. Mcl-1, an anti-apoptotic protein belonging to the B-cell lymphoma 2 (Bcl-2) family of proteins, is upregulated in cancer cells and promotes tumor cell survival.

**Synonyms:** - AMG 397 - AMG-397 - AMG397 - MCL-1 inhibitor AMG 397 - MURIZATOCLAX - Myeloid Cell Leukemia 1 Inhibitor AMG 397