Carbon C 11-osimertinib

**Semantic type:** Indicator, Reagent, or Diagnostic Aid|Organic Chemical|Pharmacologic Substance

**Definition:** A radioconjugate composed of osimertinib, a third-generation, orally available, irreversible, mutant-selective, epidermal growth factor receptor (EGFR) inhibitor, labeled with the positron-emitting isotope carbon C 11, with potential use in imaging via positron emission tomography (PET). Upon intravenous administration of carbon C 11 osimertinib, the osimertinib targets and binds to mutant forms of EGFR on tumor cells. Upon PET imaging, this radioligand may allow for the assessment of EGFR mutant-expressing tumor cells. This also allows assessment of osimetinib's pharmacokinetic profile and affinity of EGFR mutant-positive cancer cells and may identify patients who may respond well to osimertinib.

**Synonyms:** - 11C-osimertinib - [11C] Osimertinib - [11C]AZD9291