Activating PPM1D Gene Mutation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A change in the nucleotide sequence of the PPM1D gene that results in constitutive activation of protein phosphatase 1D and its downstream signaling pathways.

**Synonyms:** - Activating IDDGIP Gene Mutation - Activating PP2C-DELTA Gene Mutation - Activating Protein Phosphatase 1D Gene Mutation - Activating Protein Phosphatase 1D Magnesium-Dependent, Delta Isoform Gene Mutation - Activating Protein Phosphatase 2C, Delta Isoform Gene Mutation - Activating Protein Phosphatase, Mg2+/Mn2+ Dependent 1D Gene Mutation - Activating WIP1 Gene Mutation - Activating Wild-Type p53-Induced Phosphatase 1 Gene Mutation - PPM1D Activating Mutation