Safingol

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A saturated derivative of sphingosine. As an inhibitor of protein kinase C (PKC), safingol competitively binds to the regulatory phorbol-binding domain of PKC, a kinase involved in tumorigenesis. This agent has been shown to act synergistically with other chemotherapeutic agents and may potentiate chemotherapy drug-induced apoptosis in vitro and in vivo.

**Synonyms:** - (2S,3S)-2-Amino-1,3-Octadecanediol - Kynacyte - L-(-)-threo-Sphingnine - L-Threo-Dihydrosphingosine - L-Threo-Dihydrosphingosine - L-threo-2-Amino-1,3-octadecanediol - L-threo-dihydrosphingosine - SAFINGOL - SPC-100270 - Sphinganine - safingol