Allogeneic CMV Antigen-specific CD4+/CD8+ T-lymphocytes

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A population of allogeneic T-lymphocytes specifically reactive to cytomegalovirus (CMV) with potential antiviral activity. Allogeneic CMV antigen-specific T-cells are prepared via ex vivo stimulation of donor-derived peripheral blood mononuclear cells (PBMCs) with major cytomegalovirus structural protein, pp65 (ppUL83). T-cells that secrete interferon (IFN)-gamma in response to pp65 antigen exposure are selected and expanded for administration. Administration of the CMV antigen-specific CD4+ and CD8+T-lymphocytes into hematopoietic stem cell transplant (HSCT) or immunocompromised patients infected with CMV may potentially reconstitute virus-specific responses, thereby controlling CMV infections.

**Synonyms:** - Allogeneic CMV-specific Antigen-selected T-cells - Allogeneic Cytomegalovirus-specific CD4+ and CD8+ T-cells - Allogeneic Cytomegalovirus-specific CD4+ and CD8+ T-lymphocytes