CD45RA-depleted Donor T-lymphocytes

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of donor lymphocytes that have been depleted of CD45RA-positive cells, that can potentially be used for immune reconstitution purposes. CD45RA depletion results in a cellular product that contains a high amount of memory T-cells (Tm). Upon infusion of the allogeneic CD45RA-depleted T-lymphocytes after a hematopoietic cell transplantation (HCT), these cells provide Tm recovery and are able to prevent viral infections. The depletion of the CD45RA-positive cells reduces the risk of graft-versus-host disease (GvHD) upon infusion. CD45RA is expressed on naive T-cells, whereas Tm cells are CD45RA-negative. Naive T-cells have the potential to induce GvHD.

**Synonyms:** - CD45RA-depleted Allogeneic T-cells - CD45RA-depleted Allogeneic T-lymphocytes - CD45RA-depleted Donor T-cells - Donor CD45RA-depleted (memory) T-cells