Activating JAK2 Gene Mutation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A change in the nucleotide sequence of the JAK2 gene that results in constitutive activation of both tyrosine-protein kinase JAK2 and its downstream signaling pathways.

**Synonyms:** - Activating JAK-2 Gene Mutation - Activating JAK2 Mutation - Activating JTK10 Gene Mutation - Activating Janus Kinase 2 Gene Mutation - JAK2 Activating Gene Mutation - JAK2 Activating Mutation