Activating IRAK1 Gene Mutation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A change in the nucleotide sequence of the IRAK1 gene that results in constitutive activation of both interleukin-1 receptor-associated kinase 1 protein and its downstream signaling pathways.

**Synonyms:** - Activating IRAK Gene Mutation - Activating IRAK1 Mutation - Activating Interleukin 1 Receptor Associated Kinase 1 Gene Mutation - Activating Interleukin-1 Receptor-Associated Kinase 1 Gene Mutation - Activating pelle Gene Mutation - IRAK1 Activating Gene Mutation - IRAK1 Activating Mutation