Activating TYK2 Gene Mutation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A change in the nucleotide sequence of the TYK2 gene that results in constitutive activation of both non-receptor tyrosine-protein kinase TYK2 protein and its downstream signaling pathways.

**Synonyms:** - Activating JTK1 Gene Mutation - Activating TYK2 Mutation - Activating Tyrosine Kinase 2 Gene Mutation - TKY2 Activating Gene Mutation - TYK2 Activating Mutation