Nijmegen-Bethesda Assay

**Semantic type:** Laboratory Procedure

**Definition:** A modification of the Bethesda Assay where the pH and the protein concentration of the test mixture is further standardized, such that the factor VIII coagulant activity (FVIII:C) in the test mixture is less prone to artifactual deterioration and the test has improved specificity.

**Synonyms:** - Bethesda Assay with Nijmegen Modification