Gusperimus Trihydrochloride

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A derivative of the antitumor antibiotic spergualin with immunosuppressant activity. Gusperimus inhibits the interleukin-2-stimulated maturation of T cells to the S and G2/M phases and the polarization of the T cells into IFN-gamma-secreting Th1 effector T cells, resulting in the inhibition of growth of activated naive CD4 T cells; this agent may suppress growth of certain T-cell leukemia cell lines. (NCI04)

**Synonyms:** - (+-)-15-Deoxyspergualin - (+/-)-15-Deoxyspergualin Hydrochloride - (+/-)-Deoxyspergualin Hydrochloride - 1-Amino-19-guanidino-11-hydroxy-4,9,12-triazanonadecane-10,13-dione - 15-Deoxyspergualin - 15-Deoxyspergualin Hydrochloride - 7-[(Aminoiminomethyl)amino]-N-[2-[[4-[(3-aminopropyl)amino]butyl]amnio]-1-hydroxy-2-oxoethyl]heptanamide - BMS-181173 - BMY-42215-1 - DSG - Deoxyspergualin - GUSPERIMUS TRIHYDROCHLORIDE - N-[[[4-[(3-Aminopropyl)amino]-butyl]carbamoyl]hydroxymethyl]-7-guanidinoheptanamide - NKT-01 - Spanidin