High-Dose Methotrexate Regimen

**Semantic type:** Therapeutic or Preventive Procedure

**Definition:** A regimen consisting of high-dose methotrexate that may be used in the treatment of chronic lymphocytic leukemia (CLL); small lymphocytic, primary central nervous system (CNS), and diffuse large B-cell lymphomas; bone cancer, breast cancer leptomeningeal metastases, and Bing-Neel syndrome manifestation of Waldenstrom macroglobulinemia.

**Synonyms:** - High-Dose MTX Regimen - High-Dose Methotrexate Sodium Regimen - Methotrexate High-Dose Regimen - Methotrexate Sodium High-Dose Regimen