Nuvisertib

**Semantic type:** Pharmacologic Substance

**Definition:** An orally available, second-generation and selective ATP-competitive inhibitor of proviral integration site for Moloney murine leukemia virus (PIM) kinases, with potential antineoplastic activity. Upon oral administration, nuvisertib selectively binds to and prevents the activation of the PIM kinases. This prevents the activation of PIM-mediated signaling pathways and inhibits proliferation in cells that overexpress PIM. PIMs, constitutively active proto-oncogenic serine/threonine kinases, are upregulated in various types of cancers and play key roles in tumor cell proliferation and survival.

**Synonyms:** - 2-((1R,4R)-4-((3-(3-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-6-yl)amino)cyclohexyl)propan-2-ol - NUVISERTIB - PIM Inhibitor TP-3654 - PIM Kinase Inhibitor TP-3654 - SGI 9481 - SGI-9481 - SGI9481 - TP 3654 - TP-3654 - TP3654