Activating ERK Family Gene Mutation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A mutation in a ERK family gene that encodes a constitutively active MAP family serine/threonine-protein kinase and results in aberrant activation of its downstream pathways.

**Synonyms:** - Activating ERK Mutation - Activating Extracellular Signal-Regulated Kinase Family Gene Mutation - Activating MAPK Family Gene Mutation - Activating MAPK Mutation - Activating Mitogen-Activated Protein Kinase Family Gene Mutation