BR96-Doxorubicin Immunoconjugate

**Semantic type:** Amino Acid, Peptide, or Protein|Pharmacologic Substance

**Definition:** An antibody-drug conjugate composed of the chimeric monoclonal antibody BR96 chemically linked to the cytotoxic drug doxorubicin. The antibody moiety of BMS-182248-1 binds to Lewis Y, a cell surface antigen expressed on many solid tumor types. Thus, the doxorubicin conjugate is targeted specifically to Lewis Y-expressing tumor cells, where it intercalates with DNA, thereby inhibiting DNA replication and repair, RNA synthesis and protein synthesis. (NCI)

**Synonyms:** - BMS-182248-01 - BR96-DOX - BR96-DOX immunoconjugate - BR96-Doxorubicin - BR96-Doxorubicin Conjugate - SGN-15 - cBR96-Doxorubicin Immunoconjugate