Revdofilimab

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** An agonistic humanized IgG1 monoclonal antibody that recognizes the co-stimulatory receptor OX40 (CD134; tumor necrosis factor receptor superfamily member 4; TNFRSF4), with potential immunostimulatory activity. Upon administration, revdofilimab selectively binds to and activates OX40. This may induce the proliferation of memory and effector T-lymphocytes and inhibit the function of T-regulatory cells (Tregs) in the tumor microenvironment (TME). OX40, a cell surface glycoprotein and member of the tumor necrosis factor receptor superfamily (TNFRSF), is expressed on T-lymphocytes and plays an essential role in T-cell activation and differentiation.

**Synonyms:** - ABBV 368 - ABBV-368 - ABBV368 - Agonistic Anti-OX40 Monoclonal Antibody ABBV-368 - Anti-OX40 Agonist Monoclonal Antibody ABBV-368 - Anti-OX40 Agonistic Monoclonal Antibody ABBV-368 - PR1628103 - REVDOFILIMAB