MetAP2 Inhibitor APL-1202

**Semantic type:** Pharmacologic Substance

**Definition:** An orally available inhibitor of methionine aminopeptidase II type (MetAP2) with potential antiangiogenic and antineoplastic activities. Upon administration, APL-1202 binds to and reversibly inhibits MetAP2, thereby preventing MetAP2-mediated signal transduction pathways. This may suppress endothelial cell growth and inhibit tumor angiogenesis, resulting in tumor cell death. MetAP2, a member of the dimetallohydrolase family, is upregulated in certain tumor cell types and plays a key role in angiogenesis, proliferation and survival.

**Synonyms:** - APL 1202 - APL-1202 - APL1202 - Methionine Aminopeptidase Type II Inhibitor APL-1202