Recombinant Human Plasminogen Kringle 5 Domain ABT 828

**Semantic type:** Pharmacologic Substance

**Definition:** A recombinant human plasminogen kringle 5 domain with potential antiangiogenic and antineoplastic activities. Upon administration, recombinant human plasminogen kringle 5 domain ABT 828 may promote caspase activity and apoptosis in proliferating endothelial cells, thereby inhibiting migration. Kringle 5 (K5), an internal proteolytic fragment of plasminogen specifically inhibits endothelial cell growth via its interaction with endothelial cell surface ATP synthase, which sequentially triggers the activation of caspases -8, -9, and -3.

**Synonyms:** - ABT 828 - ABT-828 - ABT828 - rhK5