Differentiated Penile Intraepithelial Neoplasia, Human Papillomavirus-Independent

**Semantic type:** Neoplastic Process

**Definition:** Intraepithelial neoplasia of the penis that is not caused by human papillomavirus infection. It usually presents as a solitary white or pink macule or plaque that may be slightly elevated. A background of long-standing lichen sclerosus is often present. It is characterized by a thickened epithelium, subtle abnormal cellular maturation, and atypical basal layer cells. Parakeratosis is common. (WHO 2016)

**Synonyms:** - Differentiated (Simplex) PeIN - Differentiated (Simplex) Penile Intraepithelial Neoplasia - Differentiated PeIN - Differentiated Penile Intraepithelial Neoplasia - Differentiated Penile Intraepithelial Neoplasia, HPV-Independent