CD3+/CD19+ Cell-depleted Unrelated or Partially Matched Donor-derived Allogeneic Peripheral Blood Stem Cells

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of allogeneic peripheral blood stem cells (PBSCs) from an unrelated or partially matched related donor that have been selectively depleted of CD3-positive (CD3+) T-cells and CD19-positive (CD19+) B-cells via leukapheresis with potential immune reconstituting activity. The CD3+/CD19+ cell-depleted PBSCs are used for allogeneic hematopoietic cell transplantation (HCT) and may allow for rapid and sustained engraftment, immune reconstitution, and may prevent or reduce graft-versus-host disease (GvHD) and Epstein-Barr virus (EBV)-driven post-transplant lymphoproliferative disorders.

**Synonyms:** - CD3+ T-cell-depleted /CD19+ B-cell-depleted Unrelated or Partially Matched Donor-derived Allogeneic Peripheral Blood Stem Cells - CD3+ and CD19+ Cell-depleted Allogeneic PBSCs Derived from an Unrelated or Partially Matched Donor - CD3+/CD19+ Cell-depleted Unrelated or Partially Matched Donor-derived Allogeneic PBSCs