Uzatresgene Autoleucel

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** Autologous human T-lymphocytes transduced with a retroviral vector encoding a T-cell receptor (TCR) specific for the human melanoma antigen A4 (MAGE-A4) and the CD8alpha co-receptor, with potential immunostimulatory and antineoplastic activities. Upon leukapheresis, isolation, transduction, expansion ex vivo, and reintroduction into the patient, uzatresgene autoleucel bind to tumor cells expressing MAGE-A4. This may result in both inhibition of growth and increased cell death of MAGE-A4-expressing tumor cells. The tumor-associated antigen MAGE-A4, a member of the MAGE-A family of cancer testis antigens, is overexpressed by a variety of cancer cell types. Co-expression of CD8alpha may broaden the immune response against tumors and increase antitumor activity by converting CD4+ helper T-cells into CD8+ cytotoxic T-cells.

**Synonyms:** - ADP-A2M4CD8 - Autologous Genetically-modified MAGE-A4 C1032 CD8alpha T Cells - Autologous Genetically-modified MAGE-A4 C1032 CD8alpha T Lymphocytes - Autologous Genetically-modified Melanoma Antigen A4 CD8alpha T Cells - Autologous MAGE-A4 C1032 TCR-modified CD8alpha T Cells - Autologous TCR-transduced MAGE-A4 C1032 CD8alpha T Cells - MAGE-A4 SPEAR CD8alpha T-cells - MAGE-A4-specific TCR gene-transduced C1032 CD8alpha T-lymphocytes - SPEAR T-cell ADP-A2M4CD8 - UZATRESGENE AUTOLEUCEL