Autologous Active IL-7 Receptor Co-expressing GD2-specific CAR T-cells

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the human tumor-associated antigen (TAA) GD2, and the constitutively active interleukin 7 (IL-7) receptor (C7R), with potential antineoplastic activity. Upon intravenous administration, autologous active IL-7 receptor co-expressing GD2-specific CAR T-cells target, bind to, and induce selective toxicity in GD2-expressing tumor cells. C7R triggers IL-7-mediated signaling that promotes T-cell proliferation, survival, and anti-tumor activity. GD2, a disialoganglioside and TAA, is overexpressed in a variety of tumor cell types.

**Synonyms:** - Autologous C7R-GD2.CART Cells - Autologous T-lymphocytes Expressing GD2-specific Chimeric Antigen and Constitutively Active IL-7 Receptors - Constitutively Active IL-7 Receptor Co-expressing GD2-specific CAR T-cells