Bexarotene

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A synthetic retinoic acid agent with potential antineoplastic, chemopreventive, teratogenic and embryotoxic properties. Bexarotene selectively binds to and activates retinoid X receptors (RXRs), thereby inducing changes in gene expression that lead to cell differentiation, decreased cell proliferation, apoptosis of some cancer cell types, and tumor regression. (NCI04)

**Synonyms:** - 3-methyl TTNEB - 4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic Acid - BEXAROTENE - LGD 1069 - LGD-1069 - LGD1069 - LGD1069 - Targretin - Targretin - bexarotene