Tuspetinib

**Semantic type:** Pharmacologic Substance

**Definition:** A selective, reversible type I inhibitor of FMS-like tyrosine kinase 3 (FLT3; CD135; STK1; FLK2) with potential antineoplastic activity. Upon administration, tuspetinib reversibly binds to and inhibits the activity of FLT3. This inhibits the proliferation of FLT3-expressing cancer cells. FLT3, a class III receptor tyrosine kinase (RTK), is overexpressed or mutated in most B-lineage neoplasms and in acute myeloid leukemias.

**Synonyms:** - FLT3 Inhibitor HM43239 - FMS-like Tyrosine Kinase 3 Inhibitor HM43239 - HM 43239 - HM-43239 - HM43239 - TUSPETINIB