Biricodar Dicitrate

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** The dicitrate salt of a synthetic pipecolinate derivative with potential chemosensitizing activity. Biricodar binds directly to the plasma membrane drug-efflux pumps P-glycoprotein (P-gp) and multidrug resistance protein 1 (MRP-1) and inhibits their activities, which may result in increased intracellular accumulation and retention of cytotoxic agents.

**Synonyms:** - BIRICODAR DICITRATE - Incel - Incel VX-710 - VX-710