Autologous Tn-MUC1-specific CAR T-lymphocytes

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) Tn glycoform of mucin-1 (Tn-MUC1; TnMUC1), with potential antineoplastic and immunostimulating activities. Upon re-introduction into the patient, the autologous Tn-MUC1-specific CAR T-lymphocytes specifically recognize and induce selective toxicity in TnMUC1-expressing tumor cells. TnMUC1 is overexpressed in certain tumor types.

**Synonyms:** - Anti-TnMUC1-CAR-expressing Autologous T-lymphocytes - Autologous Anti-TnMUC1-CAR-expressing T-lymphocytes - Autologous CART-TnMUC1 Cells - Autologous Tn-MUC1-specific CAR T Cells - Autologous TnMUC1-targeted Genetically-Modified CAR T Cells