Allogeneic CRISPR-Cas9 Engineered Anti-CD19 CAR T Cells CTX110

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of human allogeneic T-lymphocytes transduced with a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD19 and gene-edited with the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 nuclease complex to eliminate endogenous TCR, with potential immunostimulating and antineoplastic activities. Upon introduction into the patient, the allogeneic CRISPR-Cas9 engineered anti-CD19 CAR T-cells CTX110 recognize and bind to CD19-overexpressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of CD19-positive tumor cells. Removal of endogenous TCR reduces the risk of graft-versus-host disease (GvHD). CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies.

**Synonyms:** - Allogeneic Anti-CD19 CAR CRISPR-edited T Cells CTX110 - Allogeneic Anti-CD19 CAR-T Cells CTX110 - Allogeneic CRISPR-Cas9 Gene-edited CD19-directed CAR T-cells CTX110 - Allogeneic CRISPR-Cas9-Engineered Anti-CD19 CAR T Cells CTX110 - CTX 110 - CTX-110 - CTX101 - CTX110