SERD SHR9549

**Semantic type:** Pharmacologic Substance

**Definition:** An orally available selective estrogen receptor degrader/downregulator (SERD), with potential antineoplastic activity. Upon oral administration, SERD SHR9549 specifically targets and binds to the estrogen receptor (ER) and induces a conformational change that promotes ER degradation. This prevents ER-mediated signaling and inhibits both the growth and survival of ER-expressing cancer cells.

**Synonyms:** - SHR 9549 - SHR-9549 - SHR9549 - Selective Estrogen Receptor Degrader SHR9549 - Selective Estrogen Receptor Downregulator SHR9549