Samarium Sm 153-DOTMP

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A radioconjugate composed of the phosphonic acid chelator DOTMP (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethylenephosphonic acid) conjugated to the beta- and gamma-emitting radioisotope samarium Sm 153, with potential antineoplastic activity. Upon administration of samarium Sm 153-DOTMP, the DOTMP moiety targets and binds to growing bone, thereby selectively delivering samarium Sm 153-mediated cytotoxic radiation to bone tumor and metastases, which may help destroy bone metastases and mitigate pain from bone metastases.

**Synonyms:** - 153 Sm-DOTMP - 153Sm-DOTMP - CycloSam - DOTMP SM-153 - Sm-153-1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetra(methylene)phosphonic Acid - Sm-153-1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetrayltetrakis(methylene)tetrakisphosphonic Acid - Sm-153-DOTMP