Ifebemtinib

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** An orally bioavailable inhibitor of the non-receptor, cytoplasmic tyrosine kinase protein tyrosine kinase 2 (focal adhesion kinase 1; FAK1; FAK: PTK2) with potential antineoplastic activity. Upon oral administration, ifebemtinib targets and inhibits, in an adenosine triphosphate (ATP)-competitive manner, PTK2. This prevents PTK2-mediated downstream signaling and inhibits migration, proliferation, invasion, and survival in PTK2-overexpressing tumor cells. The cytoplasmic tyrosine kinase PTK2, a signal transducer for integrins overexpressed in various tumor cell types, is involved in tumor cell invasion, migration and proliferation.

**Synonyms:** - BI 853520 - BI-853520 - BI853520 - FAK1 Inhibitor IN10018 - IFEBEMTINIB - IN 10018 - IN-10018 - IN10018 - PTK2 Inhibitor IN10018 - Protein Tyrosine Kinase 2 Inhibitor BI 853520 - Protein Tyrosine Kinase 2 Inhibitor IN10018