Peginterferon Lambda-1A

**Semantic type:** Pharmacologic Substance

**Definition:** A covalent conjugate of human recombinant interferon (IFN) lambda-1 (IFN-L1; IL-29), a type III IFN, and a linear polyethylene glycol (PEG) chain, with antiviral and immunomodulating activities. Upon administration, peginterferon lambda-1A targets and binds to type III IFN receptors, which activates the JAK-STAT signaling cascade and upregulates IFN-stimulated genes (ISGs), leading to cell-mediated immune responses. The PEG chain of peginterferon lambda-1A lowers the clearance of interferon lambda-1A, thereby extending the duration of its therapeutic effects. Endogenous IFN-L1 is produced following viral infection and it plays a key role in innate immune response against the viral pathogens.

**Synonyms:** - PEGINTERFERON LAMBDA-1A - Peginterferon Lambda - Pegylated IFN Lambda-1a - Pegylated Interferon Lambda-1a