Guanylate Cyclase

**Semantic type:** Amino Acid, Peptide, or Protein|Enzyme

**Definition:** Guanylate cyclase (GC) is an enzyme that converts GTP to the second messenger cyclic GMP (cGMP). There are two forms: plasma membrane GCs that are receptors for hormones, and intracellular soluble GCs that are activated by the gaseous second messenger nitric oxide (NO). EC 4.6.1.2

**Synonyms:** - EC 4.6.1.2