Fostemsavir Tromethamine

**Semantic type:** Pharmacologic Substance

**Definition:** The tromethamine salt form of fostemsavir, an orally bioavailable phosphonooxymethyl prodrug of the human immunodeficiency virus type 1 (HIV-1) attachment inhibitor temsavir, with activity against HIV. Upon oral administration, fostemsavir is hydrolyzed to the active moiety temsavir. Temsavir targets and binds to the gp120 subunit within the HIV-1 envelope glycoprotein gp160. This selectively inhibits the interaction between HIV-1 virus and host cellular CD4 receptors, thereby preventing HIV-1 virus attachment. This also inhibits gp120-dependent post-attachment steps that are needed for HIV-1 viral entry into host cells.

**Synonyms:** - FOSTEMSAVIR TROMETHAMINE - Rukobia - Rukobia