Piclidenoson

**Semantic type:** Pharmacologic Substance

**Definition:** An orally bioavailable, adenosine A3 receptor (A3AR) agonist with potential anti-inflammatory activity. Upon administration, piclidenoson selectively targets, binds to and activates the cell surface-expressed A3AR, thereby activating transduction pathways in which A3AR plays a key role. This inhibits nuclear factor-kappa B (NF-kB) signaling and inhibits inflammatory cytokine production, such as tumor necrosis factor (TNF) and several interleukins. A3AR, a G protein-coupled receptor, plays a key role in many inflammatory diseases, and in certain types of cancer.

**Synonyms:** - 1-Deoxy-1-(6-(((3-iodophenyl)methyl)amino)-9H-purin-9-yl)-N-methyl-beta-D-ribofuranuronamide - 3-IB-Meca - CF-101 - CF101 - IB-MECA - Methyl 1-[N6-(3-iodobenzyl)-adenin-9-yl]-b-D-ribofuronamide - N(6)-(3-Iodobenzyl)-5'-N-methylcarboxamidoadenosine - N(6)-Ibamu - PICLIDENOSON - SI-615 - beta-D-Ribofuranuronamide, 1-Deoxy-1-(6-(((3-iodophenyl)methyl)amo)-9H-purin-9-yl)-N-methyl-