Garadacimab

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A humanized monoclonal antibody against the activated coagulation factor XIIa (FXIIa), with potential anti-inflammatory and anticoagulant activities. Upon administration, garadacimab targets and binds to FXIIa, blocking the activation of both the kallikrein-kinin system and the intrinsic pathway of coagulation. Blocking the activation of the kallikrein-kinin system may reduce inflammation as well as the production of bradykinin (BK). This may prevent BK-driven edema in hereditary angioedema (HAE). Blocking the activation of the intrinsic pathway of coagulation may lead to anti-coagulation. This may also prevent or improve pulmonary edema not associated with HAE and improve the associated decrease in blood oxygen levels.

**Synonyms:** - CSL 312 - CSL-312 - CSL312 - GARADACIMAB