Concizumab

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A humanized monoclonal antibody targeting the tissue factor pathway inhibitor (TFPI) binding site for factor Xa (FXa), the Kunitz-2 domain, with potential coagulant activity. Upon subcutaneous or intravenous administration, concizumab specifically targets and binds to the Kunitz-2 domain of TFPI, thereby preventing the activity of TFPI. This prevents TFPI from binding to and blocking the active site of FXa. As TFPI reversibly inhibits FXa, concizumab prevents FXa inhibition. This allows for the activation and continuation of the coagulation cascade, which may prevent bleeding in hemophilia and may rebalance hemostasis.

**Synonyms:** - Alhemo - CONCIZUMAB