Miriplatin

**Semantic type:** Pharmacologic Substance

**Definition:** A lipophilic platinum complex and oxaliplatin analog that contains two myristate chains, with potential antineoplastic activity. Upon administration of miraplatin, the platinum moiety forms complexes with nucleophilic groups such as GC-rich sites in DNA, inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links, resulting in apoptosis and cell growth inhibition. Compared to platinum alone, the lipophilic formulation allows increased delivery of platinum to the tumor site, thereby increasing efficacy while reducing systemic toxicity.

**Synonyms:** - MIRIPLATIN - Miripla - SM-11355