Activating ERBB2 Point Mutation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A point mutation in the nucleotide sequence of the ERBB2 gene that that results in constitutive receptor tyrosine-protein kinase erbB-2-dependent signal transduction and activation of downstream signaling pathways.

**Synonyms:** - Activating ERBB2 Gene Point Mutation - Activating HER2 Point Mutation - CD340 Activating Point Mutation - ERBB2 Activating Point Mutation - HER-2 Activating Point Mutation - HER2 Activating Point Mutation - HER2/Neu Activating Point Mutation - c-erbB2 Activating Point Mutation