Iboctadekin

**Semantic type:** Amino Acid, Peptide, or Protein|Pharmacologic Substance

**Definition:** A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine interleukin-18 (IL-18). Produced primarily by macrophages, IL-18 induces the production of interferon-gamma (IFN-gamma), and enhances the activity of natural killer (NK) and cytotoxic T lymphocytes (CTL). As a potential immunotherapeutic agent, iboctadekin displays antitumor effects in vitro and in animal models. (NCI04)

**Synonyms:** - Human Interleukin-18 (Recombinant, Expressed in Escherichia coli) - Human Recombinant Interleukin-18 - IBOCTADEKIN - IFN-Gamma-Inducing Factor - IL-18 - Interferon-Gamma-Inducing Factor - Interleukin-18 - Recombinant Interleukin-18 - SB 485232 - SB-485232