Epilepsy, Focal, with Speech Disorder and with or without Intellectual Developmental Disorder

**Semantic type:** Disease or Syndrome

**Definition:** An autosomal dominant condition caused by mutation(s) in the GRIN2A gene, encoding glutamate receptor ionotropic NMDA 2A. It is characterized by childhood-onset seizures affecting the temporal lobe or rolandic area of the brain, with a variable phenotype. It often affects speech and language.

**Synonyms:** - Aphasia, Acquired, with Epilepsy - Epilepsy, Focal, with Speech Disorder and with or without Mental Retardation - FESD with or without Mental Retardation